International Space Station (ISS) marks quarter of a century, begins 26th year of humans living in space, 292 unique individuals from 26 countries, some people with multiple visits. ISS enables 3,000+ experiments / innovations in microgravity, testing technologies for Artemis / other missions to the Moon and beyond, including water recycling, oxygen generation, hydroponic gardening, radiation protection and 3D printing. Health studies on bone loss, vision impairment and mental function inform countermeasures for Artemis crews. ESM of Artemis Orion spacecraft draws from ESA vehicle used for ISS resupply, and proposed Lunar Gateway incorporates Canadarm. ISS pioneers international collaboration and fosters diplomacy, modeling global partnerships in fields like asteroid mining and space tourism. ISS research improves medical treatments on Earth for osteoporosis and cancer, advances water purification / sustainable technologies, inspires STEM education worldwide and symbolizes unity. A widely cited figure for ISS total cost is US$150B, with NASA share at $100B+. ISS approaches 2030 retirement but promotes a multi-world era. Axiom draws on its 3 crewed missions to ISS, works with Thales Alenia (developer / builder of ISS Harmony, Tranquility and Columbus units) to develop modules that attach to ISS and then become independent – providing a unique bridge to new space stations. Starlab is a joint development among Voyager, Airbus, Mitsubishi and MDA. Vast is building Haven. Blue Origin, partnering with Sierra Space, is building Orbital Reef. (Image Credits: NASA, pictured: Jonny Kim, Zena Cardman)