As Americans, Chinese, Indians and other Asian, African and European peoples, enterprises, organizations and nations advance toward mid / late 21st Century, pioneering national and international plans aim to explore and develop the Solar System outer zones—the gas giants (Jupiter, Saturn, Uranus, Neptune), their hundreds of satellite worlds, the 3rd Zone of the Kuiper Belt, and the Milky Way Galaxy beyond. These regions encompass 99% of the Solar System known planetary mass, and represent the next frontier enabled by Earth-Moon (CisLunar) baseline infrastructure, progressing through asteroids and Mars. Leveraging the Moon as an “8th Continent” launch pad will enable more efficient deep-space propulsion (lunar water ice deposits, Helium-3 mining, regolith processing) and permanent human-occupied outposts (Artemis base, International Lunar Research Center, Moon Village). As spacecraft JUICE, Europa Clipper and New Horizons prepare for Jupiter or Kuiper Belt exploration, missions such as Dragonfly, Tianwen-3, -4, -5, and others are under development—sparking a potential golden age of Solar System exploration. Wu Weiren (Chief Designer of the China lunar exploration program and President of the International Deep Space Exploration Association), and Narendra Modi (Prime Minister of India) are both championing ambitious Solar System exploration, focusing on deep space. Every planet, moon and small body holds insights into Solar System origins, potential of extraterrestrial life and habitability. Visions for the late 21st Century include crewed journeys to the outer planets, in-situ exploration of icy moons with subsurface oceans, and Kuiper Belt outposts as stepping stones toward interstellar aspirations. (Image Credits: ESO, NASA)